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Weakness, Loss Of Appetite, Confusion, Stomach Acidity, Gas, Loss Of Concentration. Are These Due To Elevated SGOT And SGPT?

Posted on Wed, 11 Jul 2012

Question: History:

Age: 32, Height: 5'7", Weight: 58Kgs

I used to have quite a few stomach upsets in the last 1 year.

7 weeks back: I had dysentry. My doctor diagnosed amoebic colitis and certain medications (which included lot of antibiotics). It took me 3 weeks to be get recovered from dysentry. I was back to absolute normal.

3 weeks back: I had a tooth root canal treatment. This again had the dosage of antibiotics and pain killers.

2 weeks back: I started to feel a lot weak, nauseate and loss of appetite. I went to my doctor. He said I have developed oral thrush and asked me to go for LFT and HIV test. HIV was negative. LFT test, i had SGPT (64) and SGOT (126) elevated. I went for ultrasound the same day and everything was normal. My doctor said, liver enzymes elevation is drug induced due to lot of antibiotics. He didn't give me any specific medication but antacid like Rantac and said it would take 4-6 weeks to recover.

Current Situation:
I still have same lot of weakness, loss of appetite, confused mind and acidity in the stomach which produces gas. I cannot concentrate properly as its been more than 2 weeks and I don't feel comfortable.

Questions:
1. Is it true that my current problems (weakness, loss of appetite etc) are due to the elevated SGOT/SGPT?
2. Is it true that enzyme elevation has happened due to antibiotics?
3. Is it to true that it would take 4-6 weeks to gain my strength back?
4. Would you suggest me for anything?
5. Is it true that once the hepatic enzymes become normal then only i would gain strength?

Wanted to know your thoughts as am very depressed. Please Help!!

Thanks

Answered by Dr. Ajit Naniksingh Kukreja (1 hour later)

Hi XXXXXXX

Thanks for posting your query
Your information is precise but unfortunately there is no detail of antibiotics or pain killers you have had

All antibiotics are not hepato toxic

But yes the weakness and loss of appetite can be due to impaired liver function which is reflected by raised enzyme levels

As I have mentioned all antibiotics are not hepatotoxic

It usually takes six weeks for any liver insult to recover

Avoid spicy and fried meals, go for a full liver function test after 6 weeks

It is a gradual process the enzymes may remain on a slightly higher level and yet you can be back to normal

Hope this helps
Am available for followup queries
Get Well Soon

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Ajit Naniksingh Kukreja (17 hours later)

Thank You doctor for your prompt reply and sorry for late follow up question.

Here is the list of medicines and report details:

1. Calpol and Montec LC for 3 Days (1st week April)
2. Amikacin Injection for 5 Days
3. IV Drips for 5 days
4. Metrogyl Compound and VSL 3 for 10 Days
5. Augmentin 525 and Zerodol P for 5 Days (during Root canal)
6. Candid Mouth paint for 5 days

Blood Report 9th May:
Platelet Count: 1.3 Lakhs/Cumm (Ref 1.5 - 4.5 lakhs/cumm)
Serum SGOT: 64 U/L (Ref 15-37)
Serum SGPT: 126 (Ref 0-42)

Currently Taking Pantocid DSR and Rantac. Also taking Enzoblend with Betonin.

Please have a look at the details of the medicine.
The weakness and other symptoms that I have are chronic. I mean I am not able to stand and walk also. Do you think this is normal?

What would you suggest doctor?

Answered by Dr. Ajit Naniksingh Kukreja (8 hours later)

Hi XXXXXXX

Thanks for your followup

Few of the medicines like Calpol & Augmentin are known hepatotoxic molecules

It would usually take six weeks as I have mentioned in my earlier reply

But the severity of your symptoms can not be correlated with the LFT reports, inability to stand and walk is great weakness

I would suggest you take adequate glucose and avoid fat and fried diet

Get LFT repeated in another lab if the weakness persists

Hope this helps
Am available for followup queries

Get Well Soon

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Ajit Naniksingh Kukreja (1 hour later)

Thanks Again Doctor.

I am going for LFT test again this saturday. If the weakness still persist and the LFT is also around the same range, then what would you suggest?

What do you think might be causing the extreme weakness if not the enzymes then? Is it something to worry about?

Answered by Dr. Ajit Naniksingh Kukreja (14 hours later)

Hi XXXXXXX

Thanks for your followup

If the LFT is normal and weakness persists you need to see a General Physician for a clinical examination

If LFT is abnormal you need to see a good Gastroentrologist

There could be many reasons, and it is not possible to elaborate them on a forum, again a clinical impression can not be arrived at without a thorough clinical examination

Just reassure yourself and wait for the fresh reports and get back to me with the same

Hope this helps
Am available for followup queries
Get Well Soon

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Ajit Naniksingh Kukreja (41 minutes later)

Thanks so Much doctor. I would definitely give you the outcome of the reports as soon as I get them. I am based in Bangalore and my brother is coming to bangalore this weekend (currently in US) to help me out.

Do you know of any good gastro in Bangalore? Is there any other way I can contact you without traveling to Gujarat? Maybe once I get the report I would post the fresh question to you again with more details.

Thanks

Answered by Dr. Ajit Naniksingh Kukreja (4 minutes later)

Hi XXXXXXX

Thanks for your followup

Unfortunately the forum rules do not allow us referring a patient to a particular consultant

Here are my details if you wish to drop down to Gujarat :

RATANDEEP SURGICAL HOSPITAL & ENDOSCOPY CLINIC
"NAKSHATRA" IInd FLOOR , XXXXXXX GALI ,MANINAGAR CROSS ROADS ,AHMEDABAD - 0000

Phone : 91-79-0000 | Fax : 91-79-0000 | Mobile : 91-0000
Email : YYYY@YYYY | WebSite : WWW.WWWW.WW - WWW.WWWW.WW
Will await your reports

Hope this helps
Am available for any followup queries
If there are no further doubts, do accept this reply and rate it

Get Well Soon

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar