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What Causes Elevated C-reactive Protein?

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Posted on Mon, 31 Aug 2015
Question: what does it mean to have elevated C-reactive protein or unspecified hypogammaglobulinemia?
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Answered by Dr. Noble Zachariah (55 minutes later)
Brief Answer:
Explained below

Detailed Answer:
Hello,

Welcome and thanks for your query.
C-reactive protein ( CRP) is a marker of inflammation.
It can be elevated in infections, autoimmune diseases and other inflammatory diseases and in malignancies.
Gammaglobulin is one of the defences the body has against infections and are part of the antibodies present against infections. The normal level of Gamma globulin is 0.7 to 1.6 g/dL. If the blood is deficient in gammaglobulins, the person is more susceptible to infections.
Do get back to me if you have more queries.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Noble Zachariah (8 hours later)
I have Sjogren's Disease, fibromyalgia, Raynauds, Osteoarthritis, and just "got over a 9 month bout with MRSA" But am still having Severe "hot Flashes", just like when I had the MRSA. I do not run temps so that is of no use. Do have an elevated sed rate. Plus for the past 3 years I have been having severe muscle cramps in my hands and feet (they turn into claws and pain level usually hits an 8) plus tn the back of my thighs from buttocks down about half way... takes your breath away. Checked electolytes (OK), no new excerises, plus the bottoms of my toes and the balls of my feet are numb. So I give up... MS or neutropathy or the sjogren's just getting worse??
doctor
Answered by Dr. Noble Zachariah (3 hours later)
Brief Answer:
Unlikely to be MS

Detailed Answer:
Welcome back.
The high ESR and CRP are related to Sjogren's . Hot flushes may be related to your sex hormonal status. Most people feel these at the time of menopause but in some women it occurs even later in life. The reason is not clear. If possible, let me know your blood FSH level.
The muscle cramps you are describing is a carpopedal spasm. The commonest cause is a change in the blood pH which occurs temporarily during fast breathing driving out the carbon dioxide. When you get it next time, try taking deep breaths in and out of a paper bag which keeps your mouth and nose covered. If you feel better and the cramps ease, then that is the cause.
MS is unusual to start at your age. Neuropathy may be a cause for the numbness in the feet. Take Bcomplex vitamins as it may help if there is an unrecognized deficiency. No harm done even if it is not the cause. Avoid alcohol.
Best wishes,


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Noble Zachariah (19 hours later)
I wish to thank you; you gave me more info in a day and half than I have gotten in months, & in some cases years with these med/ school drop outs that we in rural Colo. get. Thank you again God bless, XXXX
doctor
Answered by Dr. Noble Zachariah (3 hours later)
Brief Answer:
Welcome

Detailed Answer:
Hello XXXX,
It was nice interacting with you. Thank you.
Do get back to me if you have any queries in the future.
Wish you good health and a good day.
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Noble Zachariah

Internal Medicine Specialist

Practicing since :1974

Answered : 2319 Questions

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What Causes Elevated C-reactive Protein?

Brief Answer: Explained below Detailed Answer: Hello, Welcome and thanks for your query. C-reactive protein ( CRP) is a marker of inflammation. It can be elevated in infections, autoimmune diseases and other inflammatory diseases and in malignancies. Gammaglobulin is one of the defences the body has against infections and are part of the antibodies present against infections. The normal level of Gamma globulin is 0.7 to 1.6 g/dL. If the blood is deficient in gammaglobulins, the person is more susceptible to infections. Do get back to me if you have more queries.