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What Causes Migratory Pain Throughout Body?
Question: I just received second blood test high XXXXXXX ANA 1:640 centromere pattern after receiving a low positive 1:80 homogeneous pattern a month ago. Everything was negative. I do not have any skin related symptoms. A month ago I felt migratory pain throughout my body that went away. This is the only symptom I have. I am otherwise a healthy 32 year female. Do I have an autoimmune disease? Trying to have a baby. I had two miscarriages and my OBGYN ordered the test to see if I had an autoimmune disease.
Brief Answer:
False Positive ANA
Detailed Answer:
Thanks for contacting HCM with your health care concerns
You are concerned about having an elevated ANA. These tests are frequently called a false positive. Meaning they are positive but that you do not actually have any disease. You need to take the test in context of what symptoms you are experiencing. Are you having joint pain stiffness, joint redness or deformities unusual skin rashes or skin changes? If you are not having any of these issues then more than likely your tests are false positive.
In addition to the ANA your physician needs to run other tests like sed rate, C-reactive protein, ENA, Anti-smooth muscle antibody, Sjogrens SS-A and SS-B antibodies and scleroderma SCL 70. These are additional antibody testing that may be more specific to autoimmune disorders. If these are positive you may then need to see a rheumatologist who specializes in autoimmune disorders. As these tests are complicated and the diagnosis of an autoimmune disorder is also complicated I would recommend you get a referral to a rheumatologist.
But at this time since your symptoms are very limited and you have no other supporting lab tests for an autoimmune disorder I think you should not be worried. I do recommend though a rheumatology referral to be absolutely sure.
In summary
1. Elevated ANA possible False Positive
2. Lack of signs and symptoms of autoimmune disorder
3. Need additional labs sed rate, C-reactive protein, ENA, Anti-smooth muscle antibody, Sjogrens SS-A and SS-B antibodies and scleroderma SCL 70
4. Referral to Rheumatologist
I hope I answered your questions. Please contact HCM again with your health care concerns and questions
False Positive ANA
Detailed Answer:
Thanks for contacting HCM with your health care concerns
You are concerned about having an elevated ANA. These tests are frequently called a false positive. Meaning they are positive but that you do not actually have any disease. You need to take the test in context of what symptoms you are experiencing. Are you having joint pain stiffness, joint redness or deformities unusual skin rashes or skin changes? If you are not having any of these issues then more than likely your tests are false positive.
In addition to the ANA your physician needs to run other tests like sed rate, C-reactive protein, ENA, Anti-smooth muscle antibody, Sjogrens SS-A and SS-B antibodies and scleroderma SCL 70. These are additional antibody testing that may be more specific to autoimmune disorders. If these are positive you may then need to see a rheumatologist who specializes in autoimmune disorders. As these tests are complicated and the diagnosis of an autoimmune disorder is also complicated I would recommend you get a referral to a rheumatologist.
But at this time since your symptoms are very limited and you have no other supporting lab tests for an autoimmune disorder I think you should not be worried. I do recommend though a rheumatology referral to be absolutely sure.
In summary
1. Elevated ANA possible False Positive
2. Lack of signs and symptoms of autoimmune disorder
3. Need additional labs sed rate, C-reactive protein, ENA, Anti-smooth muscle antibody, Sjogrens SS-A and SS-B antibodies and scleroderma SCL 70
4. Referral to Rheumatologist
I hope I answered your questions. Please contact HCM again with your health care concerns and questions
Above answer was peer-reviewed by :
Dr. Raju A.T
Thank you for your response. My concern (from what I have read) is that most people with Centromere pattern at high tiers typically have a connective tissue disorder. I am waiting for a follow up call from my rheumatologist. I not sure if he tested me for the additional labs you mentioned but below are labs that had a negative result:
Anti dsDNA
Anti XXXXXXX
EC4d
BC4d
Anti-U1RNP
Anti-RNP70
Anti-SS-A
Anti-SS-B
Anti-Scl-70
Anti-CENP
Anti-Jo-1
Rheumatoid Fator IgM and IgA
Anti-Cyclic Citrulinated Peptide
Anti--Mutated Citrulinated Vimentin
Anti-Cardiolpin IgM and IgG
Anti-B2-Glycoprotein 1
Anti-Thryglobulin
Anti-Thyroid Peroxidase
Does any of this help? Thank you. Very worried and Concerned. Also will this affect my ability to have another child?
Anti dsDNA
Anti XXXXXXX
EC4d
BC4d
Anti-U1RNP
Anti-RNP70
Anti-SS-A
Anti-SS-B
Anti-Scl-70
Anti-CENP
Anti-Jo-1
Rheumatoid Fator IgM and IgA
Anti-Cyclic Citrulinated Peptide
Anti--Mutated Citrulinated Vimentin
Anti-Cardiolpin IgM and IgG
Anti-B2-Glycoprotein 1
Anti-Thryglobulin
Anti-Thyroid Peroxidase
Does any of this help? Thank you. Very worried and Concerned. Also will this affect my ability to have another child?
Brief Answer:
False positive
Detailed Answer:
Thanks for returning with additional information.
I see that you have had all the tests for connective tissue disorder completed and all appears negative. That is great news as the likelihood that you have a connective tissue disorder is low. Your one and single test ANA is positive and moderately high but it is also very nonspecific and a general screening test. You also mention that you have no other symptoms. By having only one test positive and no other significant symptoms you have a false positive ANA.
You are also concerned whether you can become pregnant again after two miscarriages. I can't say for any certainty if you will get pregnant. But I can reassure you that you do not have an autoimmune disorder that would impact your ability to get pregnant.
I hope I answered your question. Please contact HCM again with your health care questions and concerns
False positive
Detailed Answer:
Thanks for returning with additional information.
I see that you have had all the tests for connective tissue disorder completed and all appears negative. That is great news as the likelihood that you have a connective tissue disorder is low. Your one and single test ANA is positive and moderately high but it is also very nonspecific and a general screening test. You also mention that you have no other symptoms. By having only one test positive and no other significant symptoms you have a false positive ANA.
You are also concerned whether you can become pregnant again after two miscarriages. I can't say for any certainty if you will get pregnant. But I can reassure you that you do not have an autoimmune disorder that would impact your ability to get pregnant.
I hope I answered your question. Please contact HCM again with your health care questions and concerns
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
Thank you . This made me feel much better. Last question: is there a higher likelihood of developing an autoimmune disorder in the future since I have an elevated Ana result?
Brief Answer:
Not at risk for developing an autoimmune disorder
Detailed Answer:
Since all your tests are negative the likelihood of developing an autoimmune disease is very remote. The positive ANA is a false positive test. That means you are actually negative for autoimmune. Your ANA may always be positive but it means absolutely nothing. You should tell any doctor in the future that you have had prior positive ANA but it was a false positive test.
I hope I answered your question. Please contact HCM again with your health care questions and concerns
Not at risk for developing an autoimmune disorder
Detailed Answer:
Since all your tests are negative the likelihood of developing an autoimmune disease is very remote. The positive ANA is a false positive test. That means you are actually negative for autoimmune. Your ANA may always be positive but it means absolutely nothing. You should tell any doctor in the future that you have had prior positive ANA but it was a false positive test.
I hope I answered your question. Please contact HCM again with your health care questions and concerns
Note: For further information on diet changes to reduce allergy symptoms or to boost your immunity, Ask here.
Above answer was peer-reviewed by :
Dr. Vinay Bhardwaj
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