What Causes Myelofibrosis?
There are many treatment options!
Detailed Answer:
Hi! thanks for the health query for your friend!
Myelofibrosis is a treatable disease however, the therapy sometimes depends upon the stage and also the type (primary myelofibrosis or secondary to any leukemia, cancer, radiation etc..).
some of the options are:
Ruxolitinib.
Hydroxyurea
Allogeneic peripheral stem cell or bone marrow transplantation.
Thalidomide
Lenalidomide.
Pomalidomide
Splenectomy
Splenic radiation therapy or radiation to sites of symptomatic extramedullary hematopoiesis (e.g., large lymph nodes, cord compression)
Cladribine
Interferon-alpha
You need to attend the department of hemato-oncology department of Mayo clinic; the treatment is available there!
regards,
It is then better to attend palliative care unit!
Detailed Answer:
Hi! I could understand that she is now suffering from complications of different treatments which is very common.
At this stage she should consult palliative care unit and then hemato-oncologists' unit; the condition actually needs a multi-speciality care.
Staging actually done on the bone marrow biopsy and indicates the degree of fibrosis not spread of the disease like (other) malignant conditions!
Wishing her early recovery,
It should be considered malignant!
Detailed Answer:
Hi! thanks for the follow-up queries!
Theoretically it is malignant as pathology underlying myelofibrosis is like leukemias and some cases convert to leukemias also!
Scarring/fibrosis is the hallmark of this disease.
Pain especially bone pain is generally severe and is a common presentation.
Survival is restricted due to age, underlying poor health and adverse effects of the therapies.
regards,