
What Causes Severe Diarrhea While On Losartan Potassium And Spironolactone?

I would recommend as follows:
Detailed Answer:
Hello!
Welcome on HCM!
Regarding your concern, I would explain that diarrhea is a known adverse effect related to losartan or spironolactone.
Which of these drugs did you start first?
Is diarrhea related to starting on if these drugs?
Coming to this point, I would recommend stopping first spironolactone which has not a high influence in blood pressure values.
Some tests are also necessary to investigate for other possible causes:
- complete blood count
- lipaze and amylase for pancreas function
- potassium levels and sodium for possible imbalance
- kidney and liver function tests
- a stool analysis or bacterial culture.
If all these tests result normal and diarrhea doesn't stop after stopping spironolactone, I would recommended stopping also losartan.
In such case I would recommend starting amlodipine in order to help maintain a normal blood pressure.
Hope to have been helpful!
Kind regards,
Dr.Iliri


My advice as follows:
Detailed Answer:
Hello again!
Thank you for the additional information.
As, you started spironolactone first, I would recommend stopping losartan first and substitute it with amlodipine, in order to avoid fluctuations in your blood pressure values from these changes to your therapy.
If diarrhea doesn't stop, then stopping spironolactone would be the next step.
You should discuss with your doctor on the above issues.
Wishing all the best,
Dr. Iliri

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