Brief Answer: Diabetes Detailed Answer: I am sorry to note your husband's symptoms. You very correctly checked his glucose during the shaking episode. It does not appear to be a low sugar reaction, provided the meter is not inaccurate. Most meters are quite reliable, unless they are very old and damaged. Considering the 'shakiness' he is experiencing it would be worth checking his thyroid. A simple blood test called TSH ail give a fair idea about his thyroid status. It does not require any fasting and can be done at any time of the day. It would be relevant to check his glucoses at other times of the day and night too, especially when he has symptoms. Glipizide can cause low sugar. Speak with his doctor to see if he is a good candidate for other diabetes medications that cannot cause low glucose problems. Some examples include metformin and sitagliptin/saxagliptin/linagliptin/alogliptin. Once glipizide is no longer on board, the possibility of low glucose does not arise and you can pursue other potential reasons if the shakiness persists

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