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What Do My Lab Test Results Indicate?

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Posted on Mon, 13 Jun 2016
Question: Hi, my name is XXXXX and I've decided to write a brief history. I have an acute problem with tachycardia, weakness, and elevated cortisol that started 3 weeks ago. I also have vertigo and an ENT evaluated me and concluded it was not inner related, but may be vascular in nature.

3 weeks ago, I went to St. XXXXXXX and had a "DMPS challenge test" done by an integrative MD in which I was given a DMPS IV and gave a urine sample before and after to see if any levels of heavy metals were excreted. I did perfectly fine with the infusion, but the next day (20 hours later) when I returned to get a routine Vitamin IV from the same doctor, I felt lightheaded and faint, my blood pressure XXXXXXX and heart rate elevated to 135. The next two days after returning to XXXXXXX I felt very weak, although my blood pressure was low (92 systolic).

Two days later, the weakness continued, although my heart rate elevated. My heart rate remained elevated from a range of 100-120 for the next two weeks, and my blood pressure was 140/80 in a bedridden state. My normal blood pressure is 115-120 (systolic)My endocrinologist did a thorough blood workup and the only abnormality was elevated cortisol, which she said could cause tachycardia but would not cause the profound weakness. During this entire time, I was so weak that I was unable to walk to the bathroom at my home. The tachycardia was preventing me from sleeping, so my primary care doctor put me on Popranolol 10mg – 3X/Day to decrease my heart rate and Clonazepan to help me sleep.

Since that time (a week ago) I’ve regained a small amount of strength, although I am still very weak to where it is difficult to walk, and I still struggle with vertigo. My heart rate remains in the range of 85-100, although it is sporadic, and sometimes will be 111 when it is time for a dose, or as low as 74 when it is time for a dose. My blood pressure has come down to normal levels.

I had a cardiology work-up in 2012 at St. Francis Heart Hospital. Everything was normal. However, because of the sporadic nature of my heart rate and now that beta blockers are involved, I wanted to consult you.

I should also tell you that 2 episodes of weakness similar to this, without tachycardia, have happened in the past 10 years. Also, I have a small (2mm) pituitary lesion that my neurologist has been keeping an eye on for 3 years that may be a factor.

The six main symptoms are:

1) Profound Weakness
2) Tachycardia
3) Vertigo when I turn my head
4) Elevated Cortisol
5) frequent urination
6) Lightheadness

Two questions:

1) Could the vertigo/lightheadedness be a vascular problem that I should see a cardiologist for? or a neurologist?
2) I also have an intense burning in the back of my occipital region of my neck and in conjunction with the severe lightheadedness, I'm wondering what imaging I should have done? Would an MRI without contrast serve any purpose? My body doesn't do well with injections.
3) This is an acute relapse, although I've had this problem for 12 years and had multiple MRI's of my brain in the past. My neurologist is following a pituitary lesion that is 2mm. The only thing I've not had done is imaging to check about my vascular system. If my MRI's have been okay in the past, is there any reason to believe anything has changed in the last year?


Also, here are the labs I've had done so far - only 2 were abnormal - are there any more I should ask of my primary care doctor? thank you!


Labs Completed


Component
WBC
RBC
Hgb
Hct
Abnormal 44.9 Ref Range 34.5-42.8 %

MCV
MCHC
RDW
Plt
MPV
nRBCs
Neutrophil (%)
Lymph (%)
Mono (%)
Eos (%)
Baso (%)
Absolute Segmented Neutrophils
Absolute Lymphocytes
Absolute Monocytes
Absolute Eosinophils
Absolute Basophils
ESR
Metanephrone
Normetanephrine
FOLLICLE STIMULATING HORMONE
LUTEINIZING HORMONE
INSULIN LIKE GROWTH FACTOR
PROLACTIN
ALDOSTERONE/RENIN ACTIVITY RATIO
CORTISOL

ACTH
XXXXXXX R Prabhala, MD Final result
T4 FREE
XXXXXXX R Prabhala, MD Final result
TSH
XXXXXXX R Prabhala, MD Final result
METANEPHERINE,URINE 24 HOUR
XXXXXXX R Prabhala, MD Final result
ALDOSTERONE, URINE 24 HOUR
XXXXXXX R Prabhala, MD Final result
CORTISOL,URINE Abnormal 72 Ref. Range 45
XXXXXXX R Prabhala, MD Final result
METANEPHRINES,URINE
XXXXXXX R Prabhala, MD Final result
ALDOSTERONE,URINE
XXXXXXX R Prabhala, MD Final result
CoRTISOL,URINE
XXXXXXX R Prabhala, MD Final result
doctor
Answered by Dr. Dr. Erion Spaho (1 hour later)
Brief Answer:
Cervical spondylosis may explain vertigo and occipital burning.

Detailed Answer:
Hello and thanks for using HCM.

I have read your questions and understand your concerns.

Vertigo evaluated as vascular in nature, (since inner ear related vertigo is excluded by ENT) together with burning on occipital area point towards cervical spine conditions such spondylosis.

Vertigo ( if the cervical spondylosis is confirmed ) in such cases is caused by narrowing of vertebral arteries during the head and neck movement.

Occipital area burning sensation in the other hand, may be related to upper cervical nerves that supply this are compression ( occipital neuralgia ).

There is need for imaging tests such x-rays of the cervical spine to evaluate spondylosis and Doppler ultrasound in different head and neck positions to measure the vertebral arteries blood flow, in order to confirm or exclude this possibility as cause of your concerns.

Regarding to pituitary lesion, if it is confirmed that is producing ACTH, or any other pituitary hormones, it should be removed surgically, even it is a small one.

MRI of your cervical spine with vascular protocol ( without intravenous contrast ) may give valuable information about spondylosis and vascular architecture.

Weakness and fainting sensation together with lightheadedness may be related to sudden changes of your blood pressure.

A Cardiologist evaluation is necessary to understand better the cause of change in heart rate and blood pressure.

Hope you found the answer helpful.

Let me know if I can assist you further.

Take care.

Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
default
Follow up: Dr. Dr. Erion Spaho (50 minutes later)
Is it possible that I have some sort of a fungal infection in my any sinuses that may be located at the base of my head (occipital region). The reason I ask is that Tinidazole seems to help with this burning sensation.
doctor
Answered by Dr. Dr. Erion Spaho (40 minutes later)
Brief Answer:
Tinidazole is an anti-parasitic drug.

Detailed Answer:
Welcome back.

Tinidazole main use is as an anti-parasitic drug, so, fungal infection is not a possibility.

Probably Tinidazole affects peripheral nerves function as a side effect, so, this may be the cause of burning improvement.

Hope I helped you.

Greetings.
Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
Answered by
Dr.
Dr. Dr. Erion Spaho

Neurologist, Surgical

Practicing since :2004

Answered : 4500 Questions

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What Do My Lab Test Results Indicate?

Brief Answer: Cervical spondylosis may explain vertigo and occipital burning. Detailed Answer: Hello and thanks for using HCM. I have read your questions and understand your concerns. Vertigo evaluated as vascular in nature, (since inner ear related vertigo is excluded by ENT) together with burning on occipital area point towards cervical spine conditions such spondylosis. Vertigo ( if the cervical spondylosis is confirmed ) in such cases is caused by narrowing of vertebral arteries during the head and neck movement. Occipital area burning sensation in the other hand, may be related to upper cervical nerves that supply this are compression ( occipital neuralgia ). There is need for imaging tests such x-rays of the cervical spine to evaluate spondylosis and Doppler ultrasound in different head and neck positions to measure the vertebral arteries blood flow, in order to confirm or exclude this possibility as cause of your concerns. Regarding to pituitary lesion, if it is confirmed that is producing ACTH, or any other pituitary hormones, it should be removed surgically, even it is a small one. MRI of your cervical spine with vascular protocol ( without intravenous contrast ) may give valuable information about spondylosis and vascular architecture. Weakness and fainting sensation together with lightheadedness may be related to sudden changes of your blood pressure. A Cardiologist evaluation is necessary to understand better the cause of change in heart rate and blood pressure. Hope you found the answer helpful. Let me know if I can assist you further. Take care.