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What Does Titrate-up By One Unit Every 2 Days Means?

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Posted on Thu, 15 May 2014
Question: I am taking Humulin N Pen 100 Unit /ML Subcutaneious Suspension: Inject 5 unit twelve hours. Titrate up by one unit every 2 days? I am on my third day - do I Inject 6 units of NPH insulin towards fasting blood sugar in morning of 90-130? What does Titrate-up by one unit every 2 days means?
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Answered by Dr. Binu Parameswaran Pillai (41 minutes later)
Brief Answer:
You are right

Detailed Answer:
Hello,
Good day
Apart from Humulin-N, what all other diabetic medications are you taking?
Humulin-N ( NPH) is an intermediate acting insulin and the action peaks by 4 hours and total action lasts for 12-14 hours. That is why you have to inject it twice daily.
As you correctly said, titrate up by 1 unit means that you have to increase the dose by one unit every two days till your fasting blood glucose is in target range. If you are otherwise healthy and active, im for a fasting blood glucose of between 90-110. If you have long standing diabetes or heart disease etc, aim for fasting between 90-130.

Regards
Binu
Note: For further follow-up, discuss your blood glucose reports with our diabetologist. Click here.

Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Binu Parameswaran Pillai

Endocrinologist

Practicing since :2003

Answered : 1438 Questions

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What Does Titrate-up By One Unit Every 2 Days Means?

Brief Answer: You are right Detailed Answer: Hello, Good day Apart from Humulin-N, what all other diabetic medications are you taking? Humulin-N ( NPH) is an intermediate acting insulin and the action peaks by 4 hours and total action lasts for 12-14 hours. That is why you have to inject it twice daily. As you correctly said, titrate up by 1 unit means that you have to increase the dose by one unit every two days till your fasting blood glucose is in target range. If you are otherwise healthy and active, im for a fasting blood glucose of between 90-110. If you have long standing diabetes or heart disease etc, aim for fasting between 90-130. Regards Binu