
What Does My Quadruple Test Report Indicate?

These are screen tetss, need to know gestational age in weeks.
Detailed Answer:
Hi
Dr. Purushottam welcomes you to HCM virtual clinic!
Thanks for consulting at my virtual clinic. I have carefully gone through your case, and I think I have understood your concern. I will try to address your medical concerns and would suggest you the best of the available treatment options.
Basically all these reports are done as screening for the risk of various syndromes related to chromosomal problems.
All the biochemical reports are correlated to gestational age of the baby, and range of the report value is correlated with risk of particular genetic disease.
So it is very important to know LMP (last menstrual period) of patient and gestational age in weeks, when the reports are done; to know the significance of the test values. So if you can get back with this information, I can assist you better.
I hope my answer helps you.
Thanks.
Wish you great health.
Dr Purushottam


Thanks for the answer.
At time of report
LMP : 19/9/2015
gestational age : 18 Weeks and 3 days
Need to know that what risk on my baby and what I need to do next with this result.
Waiting for answer.
Thanks
MoM risk ratio - if high- Amniocentesis and chromosomal analysis.
Detailed Answer:
hi
Thanks for the details.
AFP is high for dates.
Serum HCG is normal.
E3 is low.
Inhibin A is high.
The reports are not matching with typical findings of any syndrome.
If USg has ruled out spina bifida structural anomaly then there is no need to worry about AFP.
As such the reports are correlated by genetic laboratory to find out risk for chromosomal anomalies in terms of( MoM) units.
In such situations with high MoM risk ratio, USG guided Amniocentesis and subsequent chromosomal analysis needs to be done with the help of Fetal medicine consultant and genetic laboratory.
I will suggest to get all this done before completing 20 weeks of gestation.
Please do not panic, get the tests done through proper channel and sequence.
All things will be fine.
May god bless you.
I hope this answer helps you.
Thanks
Dr Purushottam


Thanks for the detail answer.
Yes, on Monday I'll go for report.
Can you please give me more information about
Amniocentesis and subsequent chromosomal analysis
How it perform ?
What things need to take care about it ?
Is there any risk on Mom or baby by this ?
How many day it take usually ?
What is approx price of it ? and which is best lab for this ?
What can I know after this analysis ?
And what is measured by
AFP ?
Serum HCG ?
E3 ?
Inhibin A ?
Waiting for the reply
Thanks
USG guided, 30 min.chromosomal study 3 to 5 days. Usually no harm to both
Detailed Answer:
Hello, Welcome back to HCM.
Happy to answer your query.
1] Amniocentesis is done under USG guidance.
with the USG guidance amniotic fluid in the baby's sac is aspirated and is sent for chromosomal study to Genetic lab.
2] At expert hands it carries minimal risk. Usually doctor trained in fetal medicine performs the amniocentesis.It takes 30 to 40 minutes for the procedure. usually , there is no risk to mother or baby at expert hands.
3] Chromosomal study takes about 3 to 5 days, after the fluid is sent to genetic lab.
4] Cost of both procedures depends on the policy determined by respective center or the doctor or lab.
5] With chromosomal analysis, and ( FISH ) test, almost 5 diseases related to chromosomal trans locations- Mainly Down's and Turner's and some other can be definitely predicted. If test reports are normal , it rules out chromosomal abnormalities.
6] Alpha-fetoprotein (AFP) - is produced by the liver of the fetus
Human chorionic gonadotropin (hCG) - is a hormone made by the placenta
Estriol - is an estrogen made both by the placenta and the liver of the fetus
Inhibin-A - is another hormone made by the placenta.
I think I have tried to answer most of your queries.
In case of any doubt , please feel free to communicate.
Thanks
Dr Purshottam

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