** 1. Currently, polycythemia vera [PV][ is not curative but it can be controlled, [ since mutation, in the body s JAK2 gene is the main cause], with PV there is increase in both platelets and red blood cells clumping, resulting in more of clot formation and higher chances of stroke. 2. though hydroxyurea [hydrea] is a chemo toxic drug [causing leukemia], you can opt for Interferon which is not a chemo-type drug but a biological response modifier and using interferon soon after diagnosis, is often the best course. 3. since thickened blood in PV causes slowing of circulation you should keep certain things in mind: i. moderate exercise improves your blood flow and reduces chances of blood clots. [walking, leg/ankle stretches] ii. avoid tobacco in any form: since nicotine can cause your blood vessels to constrict and thereby increasing the risk of stroke. iii. avoid hot bath and keep your skin dry [apply moisturizer] iv. Inspect your hands and feet regularly as poor circulation can make prone to injuries. v. since iron load is there thus avoid iron supplements. 4. Once your hemoglobin and hematocrit values are reduced to within the reference range, thereafter the choice depends on the risks of secondary leukemias and the rate of thrombosis or bleeding. 5. In Ayurveda PV is consider under Raktapitta , and when Pitta comes in contact with rakta [blood], both being hot in nature diminishes the clotting process and produces bleeding, thus the choice of alternative treatment depends on the risks of secondary leukemias and the rate of thrombosis or bleeding.