Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. You may continue taking both the medications. Pristiq is not a sedating antidepressant. If you had problems with sedation as well as depression then paroxetine and mirtazapine would have been a better option. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. In future if you wish to contact me directly, or want to any further details about the asked query, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.