Can Depakote cause excessive salivating (Drooling)? Can Seroquel cause it? My boyfriend just got out of the hospital yesterday. He is bipolar and a severe Psychotic episode. He was diagnosed with bipolar years ago but has refused to stay on the medications for it. He is complaining about the drooling and he is not wanting to take the meds because he thinks they are causing it. I think maybe it could be from some of the other medications they gave him while he was in the hospital to calm him down, may be what is causing it, and it has not all got out of his system yet. I have read all the side affects on both medications and do not see that listed. He was also given a pheumonia (how ever that is spelled) yesterday just before he was released. Could that be causing it? Thank you