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Can I Continue Taking Itraconazole?
hi i used itra conazole for nail fungus for 2 months already before i start this medicine my ALT was 25 but after the first course of medicine it increased to 105 but my doctor in difrent country told me to countine and not be wory and after my second course it reduce to 64 but my doctor in america has some concern about this abnormality what does doctor think about my contiunion of this medicine
Wed, 17 May 2017
Hi dear. thanks for asking HealthCareMagic. I hope you're in good condition right now. I have understood your query.
may I know some things about your health:
1. how old are you?
2. do you have jaundice (yellowing skin or eyes)
3. how about the other results of laboratory, such as AST which show the liver function too? is it normal or elevated?
4. how much the dose of itraconazole you take?
5. do you take another medicine that may have interaction with itraconazole and make side effect worsen?
Firstly I would like to explain about Itraconazole, from the class of azole antifungal, which is a drug for treating fungal infection. it's true that one of the side effects from itraconazole can develop abnormal liver function test results. it occurred in 1% to 7% of patients receiving continuous therapy. the normal range of ALT is 7-56 u/L (varies depend on laboratories), so your results after consuming itraconazole were high. elevated liver enzymes possibly can show us the liver injury, it may induced by itraconazole.
if I were your treating doctor, I would suggest monitoring the liver function closely. you have to concern if the sign/symptom of liver disease develop, such as elevated ALT/AST, jaundice, elevated bilirubin. please contact your local doctor directly, if you notice these signs/symptoms: dark urine, loss of appetite, pale stools, severe stomach pain, unusual tiredness, severe nausea or vomiting, or yellowing of the skin or eyes (jaundice). it may associates with fatal liver problem. your doctor will discontinue giving itraconazole or just adjust the dose. please do not drink alcohol since it can worsen its side effect.
I hope it can be useful to your problem. if you have anything else to be discussed, please contact me via HealthCareMagic, I'd like to help you and make it more clear. Get well soon. Take care.
Regards,
dr. Asti Yuliadha
may I know some things about your health:
1. how old are you?
2. do you have jaundice (yellowing skin or eyes)
3. how about the other results of laboratory, such as AST which show the liver function too? is it normal or elevated?
4. how much the dose of itraconazole you take?
5. do you take another medicine that may have interaction with itraconazole and make side effect worsen?
Firstly I would like to explain about Itraconazole, from the class of azole antifungal, which is a drug for treating fungal infection. it's true that one of the side effects from itraconazole can develop abnormal liver function test results. it occurred in 1% to 7% of patients receiving continuous therapy. the normal range of ALT is 7-56 u/L (varies depend on laboratories), so your results after consuming itraconazole were high. elevated liver enzymes possibly can show us the liver injury, it may induced by itraconazole.
if I were your treating doctor, I would suggest monitoring the liver function closely. you have to concern if the sign/symptom of liver disease develop, such as elevated ALT/AST, jaundice, elevated bilirubin. please contact your local doctor directly, if you notice these signs/symptoms: dark urine, loss of appetite, pale stools, severe stomach pain, unusual tiredness, severe nausea or vomiting, or yellowing of the skin or eyes (jaundice). it may associates with fatal liver problem. your doctor will discontinue giving itraconazole or just adjust the dose. please do not drink alcohol since it can worsen its side effect.
I hope it can be useful to your problem. if you have anything else to be discussed, please contact me via HealthCareMagic, I'd like to help you and make it more clear. Get well soon. Take care.
Regards,
dr. Asti Yuliadha
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