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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can I Have Indication/mechanism Of Action Of Clonidine For Tourette Syndrome?

I am a mom of a son who has TS. I am taking a class where I am profiling him as a case study. In the early years of his TS (he is 23, was 9 at onset), he was treated with clonidine for his nuisance verbal and motor tics Can you please give me the indication and MOA for that medication choice? Thank you! Sorry, I didn t know it cost money for the answer. Can t afford it. Thanks
Mon, 22 Aug 2016
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Neurologist, Surgical,  's  Response
Thanks for query
Several studies have shown that Clonidine, an α (2)-adreno-ceptor agonist, is effective in relieving tics, and the mechanism of action is thought to be linked to clonidine's effect on inhibitory effect resulting from reduced noradrenergic activity.
Tourette Syndrome affects around one child in every 100 and usually begins in early childhood. During adolescence, there is a period of “pruning back” in which redundant brain connections are removed and other structural and functional brain changes occur.

During this time, around one-third of children with Tourette Syndrome will find that their tics disappear and another third are able to more effectively control their tics. The remaining third, however, will experience little or no change in their tics and are likely to remain troubled by their Tourette Syndrome symptoms into adulthood.

This phenomenon suggests that there are mechanisms in the brain that are involved in controlling tics and undergo development or re-organization in the teen years.
So clonidine has a good role in TS , ADHD and sleep onset disorder.
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Can I Have Indication/mechanism Of Action Of Clonidine For Tourette Syndrome?

Thanks for query Several studies have shown that Clonidine, an α (2)-adreno-ceptor agonist, is effective in relieving tics, and the mechanism of action is thought to be linked to clonidine s effect on inhibitory effect resulting from reduced noradrenergic activity. Tourette Syndrome affects around one child in every 100 and usually begins in early childhood. During adolescence, there is a period of “pruning back” in which redundant brain connections are removed and other structural and functional brain changes occur. During this time, around one-third of children with Tourette Syndrome will find that their tics disappear and another third are able to more effectively control their tics. The remaining third, however, will experience little or no change in their tics and are likely to remain troubled by their Tourette Syndrome symptoms into adulthood. This phenomenon suggests that there are mechanisms in the brain that are involved in controlling tics and undergo development or re-organization in the teen years. So clonidine has a good role in TS , ADHD and sleep onset disorder.