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Can Ichthyosis Be Treated Through Stem Cells Transfusion ?
My Daughter who is currently 5.5 Years old is suffering from lamellar Ichthyosis / Ichthyosis Vulgaris (different names has been used by Dermatologist) - a rare skin disease since birth.
The Child has cuts/ scaly skin on palms / soles/ joints/ neck and with itcthing. The Skin remains dry and remain hard in winters/ summers.
The child otherwise is active and is emotionally balanced.
Now we are expecting our second child in 1-2 months from now. We are planning to store/preserve the umbilical cord stem cells at the time of this delivery and if GOD is kind , we wish to use it to cure ichthyosis (skin disease) of our first child.
Now our queries are -
1) Can Ichthyosis be treated like this through Stem Cells - Is there a study or history available;
2) Would transfusing stem cells in the first child be permitted irrespective of the blood group of new born (Is it allowable even if both children have different blood group)
3) Is it 100% safe or has a side effect;
4) Does it matter which stem cell preservation company we use or we should consult Doctors (the company with history would be beneficial);
5) Any Best company that is suggestive;
6) Any Team of Doctors in India who can guide us (may be a genetic / skin specialist)
7) Is there a negative thing about this which we should we aware about;
8) Is it possible in India or we should look forward to do this outside India. If yes in which country.
We think that GOD has given us a golden opportunity which is the only chance to cure this.
The Child has cuts/ scaly skin on palms / soles/ joints/ neck and with itcthing. The Skin remains dry and remain hard in winters/ summers.
The child otherwise is active and is emotionally balanced.
Now we are expecting our second child in 1-2 months from now. We are planning to store/preserve the umbilical cord stem cells at the time of this delivery and if GOD is kind , we wish to use it to cure ichthyosis (skin disease) of our first child.
Now our queries are -
1) Can Ichthyosis be treated like this through Stem Cells - Is there a study or history available;
2) Would transfusing stem cells in the first child be permitted irrespective of the blood group of new born (Is it allowable even if both children have different blood group)
3) Is it 100% safe or has a side effect;
4) Does it matter which stem cell preservation company we use or we should consult Doctors (the company with history would be beneficial);
5) Any Best company that is suggestive;
6) Any Team of Doctors in India who can guide us (may be a genetic / skin specialist)
7) Is there a negative thing about this which we should we aware about;
8) Is it possible in India or we should look forward to do this outside India. If yes in which country.
We think that GOD has given us a golden opportunity which is the only chance to cure this.
Tue, 18 Mar 2014
Hello and welcome to healthcaremagic
I would keep a possibility of Icthyosis Vulgaris which is an autosomal dominantly inherited disease.
Lamellar icthyosis is autosomal recessively inherited and is very severe, with thick plate like scales/armour covering most of the body. In Lamellar icthyosis there is a history of consanguinity.
A number of genetic disorders are amenable to stem cells therapy, which provides the only hope for them.
Icthyosis vulgaris is due to defective fillagrin gene/mutations thereby leading to a defective epidermal barrier. Experimental mice have been studied with this gene defects and replacement of the gene defect restores epidermal barrier. But as far as I know there are no human trials till now, but surely stem cell therapy is a promising option in future medical science.
I would advice that you use a good moisturizer for her specially, in dry and cold weather, to keep her skin soft and hydrated. Migrating to a tropical country if possible would be an ideal case scenario, if that is possible.
regards
I would keep a possibility of Icthyosis Vulgaris which is an autosomal dominantly inherited disease.
Lamellar icthyosis is autosomal recessively inherited and is very severe, with thick plate like scales/armour covering most of the body. In Lamellar icthyosis there is a history of consanguinity.
A number of genetic disorders are amenable to stem cells therapy, which provides the only hope for them.
Icthyosis vulgaris is due to defective fillagrin gene/mutations thereby leading to a defective epidermal barrier. Experimental mice have been studied with this gene defects and replacement of the gene defect restores epidermal barrier. But as far as I know there are no human trials till now, but surely stem cell therapy is a promising option in future medical science.
I would advice that you use a good moisturizer for her specially, in dry and cold weather, to keep her skin soft and hydrated. Migrating to a tropical country if possible would be an ideal case scenario, if that is possible.
regards
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