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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Tramadol And Flexeril Be Taken Together?

Greetings! I have been prescribed 50 mg Tramadol daily for arthritis issues which I take in the mornings, one a day. I also have a prescription to 5 mg Flexiril which I take occasionally in the evenings. Is there a risk involved in taking both of these meds? Thanks!
Fri, 7 Apr 2017
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General & Family Physician 's  Response
HI, thanks for using healthcare magic

Unfortunately both of these medications increase the levels of a chemical called serotonin and can therefore result in levels that are too high.

This can cause serotonin syndrome which is a condition that can potentially cause fever, tremors, seizures, increased heart rate, increased blood pressure, confusion, agitation.

It would be best to substitute one of these medications to reduce any interaction.

I hope this helps
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Can Tramadol And Flexeril Be Taken Together?

HI, thanks for using healthcare magic Unfortunately both of these medications increase the levels of a chemical called serotonin and can therefore result in levels that are too high. This can cause serotonin syndrome which is a condition that can potentially cause fever, tremors, seizures, increased heart rate, increased blood pressure, confusion, agitation. It would be best to substitute one of these medications to reduce any interaction. I hope this helps