Hi, Accutane contains isotretinoin is a drug which is used to treat severe acne that hasn t responded to other treatments. This drug is vitamin A derivative (retinoid). Accutane can be associated with sexual dysfunction including sexual dysfunction including erectile dysfunction and decreased libido and that the mechanism may be a reduction in plasma testosterone. Testosterone, the major male hormone is a key driver of sexual arousal and erection. One of the proposed ways that it may produce its therapeutic effects is through suppressing testosterone levels in the body. Another possible cause of sexual problems could be the mental issues on one s sex drive. A link between Accutane and psychiatrist conditions like depression. Because depression can negatively impact your sex drive. It can cause erectile dysfunction, sometimes more than a after starting treatment. However, symptoms seemed to resolve after discontinuing the medication. Small sebaceous glands lie just under the skin surface and make an oil (sebum) that keeps the skin supple and smooth. Accutane works by reducing the production of skin s natural oil and makes the skin dry. Even glans penis becomes dry due to this therapeutic effect and dryness can lead the penis and its associated parts more prone to develop inflammation. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Zubayer Alam, General & Family Physician