2 weeks ago I had the Depo-Provera shot as a birth control method. I didn t experience any initial side effects. But this week I had a completely clear face. I had already had my cycle that ended 2 days prior to breaking out in huge pimples, zits. I have 10 on my face right now. I never had acne as a teen and even as an adult I might get one during menstrual cycles. I am completely healthy. I just had a regular check-up, a blood test and all the STD testing within the last month. I am not allergic to anything that I know of. And the only medication I m on is the B-12 shots from the same doctor to help me with weight loss( I am currently at a healthy BMI). I have been on the B-12 for the past 6 months and also have not had any side effects. Any advice on what to do??? Vitamin A, Zinc, will those help? 26 y/o female 5 5, 150lbs.