Can luau optic hztz be the cause of my annul fissures and bowel issues. I started taking it about 8 months ago and started having constipation followed by very acidic stools then got anal fissure that refuses to heal. I stopped taking the medicine for a week and started to get relief but had already scheduled Botox injections because my anus muscle had been spasming not allowing fissure to heal. I had to take medication for 3 days prior to surgery but refuse to take it. I have read others who have had same issue why is this not listed as a possible side effect? When asking my doctor months ago it was laughed off as coincidence because not a side effect? How can other people have same issue and not be considered possible culprit?