Can Nicotine Patches Cause Sudden Uterine Cramps And Pain, Similar

Can nicotine patches cause sudden uterine cramps and pain, similar to that of endometriosis? My wife put a patch on this morning and within fifteen minutes was experiencing pain and nausea that sent her back to bed. This lasted " an hour. She does have a 'mild' endometriosis. Being prone to anxiety she is envisioning worst possible case scenarios. An opinion rather than a diagnosis would be appreciated. Cheers, Doug