Hi, It is not recommended to take Oxy Elite Pro with Synthroid or any other thyroid medication without consulting with a doctor first. Oxy Elite Pro is a dietary supplement that contains caffeine, which can have a stimulant effect and increase heart rate and blood pressure. Combining it with thyroid medication could have unpredictable effects and may not be safe for everyone. In addition, it s important to note that weight loss is not solely about calorie intake and exercise. Hormonal imbalances, medication side effects, and other health conditions can affect weight loss efforts. It s important to speak with a doctor or a registered dietitian to develop a personalized plan for safe and effective weight loss, especially if you have an underlying health condition like a thyroid problem. Some general tips for weight loss include: * Eating plenty of fruits, vegetables, whole grains, and lean protein for a balanced and healthy diet Tracking your food intake and portion sizes * Incorporating regular physical activity into your routine * Staying hydrated by drinking plenty of water * Getting enough sleep and managing stress levels * Remember, sustainable weight loss takes time and patience. It s important to prioritize your overall health and well-being rather than just a number on the scale. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician