Hi, Thanks for writing in. Medical literature tells that mechanism of action of ozone is by inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Diseases treated include infected wounds, circulatory disorders, geriatric conditions, macular degeneration, viral diseases, rheumatism/arthritis, cancer, SARS and AIDS. In TMJ painful conditions ozone therapy is more effective than medication therapy in patients with high pain scores. Therapeutic modalities for the administration of intraoral ozone include irrigation with ozonized water, gas injection, topical application of ozonized oil, and gas insufflation of periodontal pockets. Some of the injection protocols are intraosseous injection of an ozone-oxygen gas mixture locally into the alveolus, subgingivally and intramuscularly into the inferior alveolar nerve area, and into the pterygoid space.