Is there any data suggesting a link between electrolyte imbalance and dehydration and depression? I suffer from major depressive disorder, which was aggravated by several weeks of secretory diarrhea. The latter seemed to be improving, so I stopped drinking pedialyte and resumed some activities that had been impossible because of the diarrhea. Shortly thereafter came very loose stools and markedly worsened depression. After two days of that, I resumed pedialite. The deep depression improved almost immediately. Thus, my question.