I have been taking the depo shot for the past year and 4 months. I recently switched gynocologists because I moved to go to university. I have had no reactions to the shot that my old gynocologist was giving me, when when I switched over, I have gotten a handful of itchy red bumps on the back of my legs. I was wondering if it had anything to do with the different place I was getting my shot? As well, I just quit smoking , so I wanted to know if maybe smoking was hiding the side effects, and they just appeared now.