Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. You mother had a stroke and the most common factor for causing stroke is smoking. Even if she was not on premarin still she might have had a stroke. So its a bit difficult to predict. The cold turkey thing is cause of sudden discontinuation of the medications and they will take time to resolve. Mostly the problem will be transient and will resolve with time. However let her take plenty of water and rest. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.