Hello! Thank you for asking on HCM!Regarding your concern i would explain that Instaflex is generally safe except for one of its ingredients, that is Cayenne pepper that may influence blood pressure and contribute to high BP. Nevertheless, when taking that medication you should consult your prescribing doctor and perform frequent check up to assure that your blood pressure has not been influenced so much. If high blood pressure is a persistent finding, then you have to modulate your anti-hypertensive therapy in order to appropriately manage your BP values. Just keep in touch with your doctor. Hope to have been helpful to you. Greetings! Dr. Iliri