I m a 63 year old man, in generally good health, 5 9 , 195 pounds. I am a muscular, athletic build. Three years ago, I had cardiac catheterization done for a blockage. At the time, I weighed 185 pounds. Question...can it be that Lisinopril is in some way responsible for the weight gain? Can it be that, plus other medications causing this unwanted gain? It is mostly belly fat. I hit the gym three times a week for Medex work, plus I walk four miles a day year round.