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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Omeprazole Cause Skin Discoloration?

I was prescribed Omeprazole (40 mg) and developed a skin discoloration on my hand. It helped my pain, but I'm concerned about the side effects. Is this common and will this go away or remain permanent? Do you recommend reducing the dosage to 20 mg?
Thank you in advance for any information you can give me.
Johanna -
Mon, 4 Dec 2017
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Ayurveda Specialist,  's  Response
**
Thanks for contacting with your health concern.

1. Rash is a documented ADR [adverse drug reaction] of Omeprazole and some recent study do have suggested that Omeprazole may induce skin pigmentation [skin hyperpigmentation]

PS. Omeprazole Induced Skin Hyperpigmentation
Prasad Thota*, Nagakishore Ch, Kalaiselvan V, Gyanendra Nath Singh
NCC-PvPI, Indian Pharmacopoeia Commission, Ghaziabad, UP, India

2. clinically significant skin hyperpigmentation may occur during the treatment with omeprazole and treating physicians should be aware of this phenomenon, and because the incidence of drug-induced hyperpigmentation is very variable thus you should talk with your attending physician as to how to proceed further.

PS. under no circumstances you should stop-change- alter the dosage without first consulting with your doctor.
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Does Omeprazole Cause Skin Discoloration?

** Thanks for contacting with your health concern. 1. Rash is a documented ADR [adverse drug reaction] of Omeprazole and some recent study do have suggested that Omeprazole may induce skin pigmentation [skin hyperpigmentation] PS. Omeprazole Induced Skin Hyperpigmentation Prasad Thota*, Nagakishore Ch, Kalaiselvan V, Gyanendra Nath Singh NCC-PvPI, Indian Pharmacopoeia Commission, Ghaziabad, UP, India 2. clinically significant skin hyperpigmentation may occur during the treatment with omeprazole and treating physicians should be aware of this phenomenon, and because the incidence of drug-induced hyperpigmentation is very variable thus you should talk with your attending physician as to how to proceed further. PS. under no circumstances you should stop-change- alter the dosage without first consulting with your doctor.