I used Splenda for three months, starting last April. By July my hair started falling out in clumps. I also got a bad rash. I hear that sucralose is connected to hair loss, unexplained rashes, itchy-dry-scalp, stiffening of the limbs and joints (which I also experienced) and possibly to blood in one's urine or semen. I'm a woman. My husband used sucralose, although not as extensively as I used it, and he got blood in his semen. When I threw out all the food products containing Splenda, the blood in his semen stopped.