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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Tramadol Interact With Plaquenil, Nortriptyline And Cymbalta?

I take plaquinel , nortriptyline and cymbalta before bed. Resently I was prescribed tramadol for my RA. I don t take it everyday but I noticed when I do take it with my other meds I have a bad burning sensation in my throat chest and ears. I didn t have this before. Is it a drug interation?
Wed, 26 Oct 2016
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General & Family Physician,  's  Response
Yes, there is a chance of drug interaction among tramadol, nortriptyline and Cymbalta. When tramadol is used along with these medicines, there is an increased chance of seizure (convulsion) and serotonin syndrome. Both are serious medical conditions requiring hospitalization.
Advice
1.     Continue nortriptyline, Cymbalta and Plaquenil as suggested by your doctor
2.     Stop tramadol
3.     Take ibuprofen or diclofenac sodium after meal for pain due to RA
I hope this information will help you. I will be happy if you ask another question
Thanks
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Does Tramadol Interact With Plaquenil, Nortriptyline And Cymbalta?

Yes, there is a chance of drug interaction among tramadol, nortriptyline and Cymbalta. When tramadol is used along with these medicines, there is an increased chance of seizure (convulsion) and serotonin syndrome. Both are serious medical conditions requiring hospitalization. Advice 1. Continue nortriptyline, Cymbalta and Plaquenil as suggested by your doctor 2. Stop tramadol 3. Take ibuprofen or diclofenac sodium after meal for pain due to RA I hope this information will help you. I will be happy if you ask another question Thanks