Cosmetic facial fillers using polyalkylimide may cause moderate to severe side effects, months after injection. Cosmetic polyalkylimide injections have increasingly been used for reconstruction of the face and body, including treatment of facial lines and folds, lip augmentation, depressed scars, enhancement of cheekbones and jaw line, replacement of facial volume lost due to age, lipoatrophy and so forth. In earlier studies and reports on polyalkylimide implant injections for cosmetic purposes, there were some significant side effects. These side effects included swelling, hardening and swollen or tender skin lesions near the injection site, as well as severe effects such as fever, arthritis and dry eyes or mouth.