Does Osteoarthritis Changes In The Knee Joint Have A Permanant Solution?

my mum z been diagnosed 2 be having spinal nerve compression from Cervical to S1 level.. with lateral canal narrowing...L4,L5,S1 spondylolisthesis...n disc herniation..z per the recent MRI...she z even got tenderness on vertebrae...she has severe unbearable pain in the legs....amounting to pseudo claudication...n while bending....n audible crepitus sort of friction between the vertebrae...n also ealy osteoarthritis changes in the knee joint with loose body..v showed n orthopedician who prescribed nervigen-p n asked us 2 take at 6 O clock everyday....may i know the significance of timing?n also idrofos-kit...plz tell me how n when iz it supoz 2 b taken..???doez thiz problem have any permanent solution?till when thez medications shud b continued???n she z also on Zix -MR...her creat iz 1.31 n urine has trace albumin...z per today z reportz...thiz NSAID s affect all thez further...???