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Does Weight Training Increase Uric Acid Level In Blood?
i have undergone 2 renal transplants. Im very fond of weight training. Recently i have seen my uric acid levels at 7.8. is it because of the weight training? im i allowed to do some weight training or no. blood pressure is normal at 130/80. pulse goes up to 115 immediately after weight training. should i stop weights? is this the cause of high uric acid in the blood. i do sweat a lot while working out
Fri, 5 Sep 2014
Hi,
Thank you for your query. I can understand your concerns.
Hyperuricemia (serum uric acid level > two standard deviations from the mean or > 7 mg/dl in males or> 6 mg/dl in females) may occur due to under-excretion of uric acid (renal impairment/ Chronic renal disease ).
Hyperuricaemia occurs in 5-84% of recipients of solid organ transplants. In transplant recipients, therapy with ciclosporin (cyclosporin) is an additional risk factor.
Exercise-induced hyperuricemia may result from decreased renal excretion of uric acid, increased synthesis of uric acid, or a combination of these two factors. It has been demonstrated that the main cause of exercise-induced hyperuricemia is not the decreased excretion but the increased synthesis
of uric acid, which is a result of excessive adenine nucleotide degradation in skeletal muscle.Intense muscle contraction leads to adenine nucleotide degradation and further to the formation of uric acid precursors, inosine and hypoxanthine in skeletal muscle.
High uric acid levels after vigorous exercise is due to the prolonged release of hypoxanthine from skeletal muscle that leads to the prolonged production of uric acid in liver.
Since you are already having risk factors for hyperuricemia,you are advised to do only aerobic exercise,not weight exercise.
Regards
Dr. T.K. Biswas M.D.
Mumbai
Thank you for your query. I can understand your concerns.
Hyperuricemia (serum uric acid level > two standard deviations from the mean or > 7 mg/dl in males or> 6 mg/dl in females) may occur due to under-excretion of uric acid (renal impairment/ Chronic renal disease ).
Hyperuricaemia occurs in 5-84% of recipients of solid organ transplants. In transplant recipients, therapy with ciclosporin (cyclosporin) is an additional risk factor.
Exercise-induced hyperuricemia may result from decreased renal excretion of uric acid, increased synthesis of uric acid, or a combination of these two factors. It has been demonstrated that the main cause of exercise-induced hyperuricemia is not the decreased excretion but the increased synthesis
of uric acid, which is a result of excessive adenine nucleotide degradation in skeletal muscle.Intense muscle contraction leads to adenine nucleotide degradation and further to the formation of uric acid precursors, inosine and hypoxanthine in skeletal muscle.
High uric acid levels after vigorous exercise is due to the prolonged release of hypoxanthine from skeletal muscle that leads to the prolonged production of uric acid in liver.
Since you are already having risk factors for hyperuricemia,you are advised to do only aerobic exercise,not weight exercise.
Regards
Dr. T.K. Biswas M.D.
Mumbai
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