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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Withdrawal From Tamoxifen Lead To Vaginal Bleeding?

Took Tamoxifen for 2 1/2 yrs. stopped in April. Had double mastectomy for LCIS 2 weeks ago. Started with vaginal bleeding 5 days after surgery. Had endometrial bx this past Monday. Bleeding stopped. Now started again. Docs thing withdrawal from Tamoxifen. Thoughts?
Mon, 22 Jun 2020
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General Surgeon,  's  Response
Hello,

As per my clinical experience, the withdrawal of Tamoxifen is usually not associated with heavy menses or vaginal bleeding. Tamoxifen is a selective estrogen receptor modulator (SERM) used in various conditions of ERPR positive breast cancer and other related conditions.

Tamoxifen is known to produce endometrial hyperplasia and that maybe a major cause of concern, when it is used for a period of 2.5
years. However, I would like to revert back to you with your biopsy report whenever available to share with me.

Take care. Hope I have answered your question. Let me know if I can assist you further.

Regards,
Dr. Bhagyesh V. Patel, General Surgeon
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Does Withdrawal From Tamoxifen Lead To Vaginal Bleeding?

Hello, As per my clinical experience, the withdrawal of Tamoxifen is usually not associated with heavy menses or vaginal bleeding. Tamoxifen is a selective estrogen receptor modulator (SERM) used in various conditions of ERPR positive breast cancer and other related conditions. Tamoxifen is known to produce endometrial hyperplasia and that maybe a major cause of concern, when it is used for a period of 2.5 years. However, I would like to revert back to you with your biopsy report whenever available to share with me. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Bhagyesh V. Patel, General Surgeon