Hi, I am a 35yr old woman who has had elevated ESR (constantly fluctuates but never goes below 35, currently at 50) and extremely bad headaches for two years now. I have had CT Scans, MRI's,Lumbar Punctures, chest X-Ray and still have had no diagnosis, I was on a high dose on Prednisone for several months but it didn't really do anything apart from make me feel worse. My doctor is now totally baffled and does not seem to know what to do next. Any idea's on what should I do next?