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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Extradural Mass,mitosis,Extramyeloid Granulocytic Sarcoma,Lympoplasmacytic Lymphoma,cancer ?

My father s histopathology (medium biopsy specimen, tissue/parafin block)results last week diagnosed the following .He had shooting pain in back & legs.Clinical diagnosis :Extradural mass at D12-L1 . Specimen : Excised Extradural Tumor D12-L1. Gross:Recd. in formalin a single greyish white irregular soft tissue peice measuring 2.4x2.00.8 cms.Cut surface is smooth & firm in consistency.Microscopic Examination:Sections are composed of Diffuse Sheets of large cells containing coarsely clumped nuchlei having prominent nucleoli and is surrounded by a distinct eosinophilic cytoplasm. Also seen are plasmacytoid cells along with granulocytic series of cells . An occasional mitosis is also observed. Interpretation/Diagnosis D/D: ? Extramyeloid Granulocytic Sarcoma ?? Lympoplasmacytic Lymphoma ??? PLasmacytoma Comments: ADV:IHC:MPO,LCA,CK,CD43,CD-38/138,CD-3 I am unable to understand the report. Kindly let me know whether it is cancer ,If yes which type of cancer , which stage, Chances ? My mail id is YYYY@YYYY (in case I lose connection) Thanks & regards
Wed, 9 May 2012
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Oncologist, Radiation,  's  Response
extradural mass at D12-L1 vertebra level means , Spinal cord is covered by dura ,pia and arachinoid covering and mass at this point is absolutely correctly given by histopatho report of biopsy(extra myeloid granuloctic sarcoma??, lymphoplasmacytic lymphoma?, plasmacytoma?)
so but all togather cancer treatment is firmly based on final diagnosis you can't treat all three differential diagnosis , so you have to finally conclude one of them by a special test so callled Immunohistochemistry which is a currently available weapon to diagnosis of cancer beside H&E Stained biopsy report,. once IHC has given report of biopsy , majority time we have to believe its finding of it and start treatment as per its report. if its lymphoma then treatment is chemotherapy followed by radiotherapy to local site, if its sarcoma treatment is chemo , if it turns plasmacytoma then radiotherapy after skeletal survey of whole body to rule out possibility of multiple myeloma.
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Extradural Mass,mitosis,Extramyeloid Granulocytic Sarcoma,Lympoplasmacytic Lymphoma,cancer ?

extradural mass at D12-L1 vertebra level means , Spinal cord is covered by dura ,pia and arachinoid covering and mass at this point is absolutely correctly given by histopatho report of biopsy(extra myeloid granuloctic sarcoma??, lymphoplasmacytic lymphoma?, plasmacytoma?) so but all togather cancer treatment is firmly based on final diagnosis you can t treat all three differential diagnosis , so you have to finally conclude one of them by a special test so callled Immunohistochemistry which is a currently available weapon to diagnosis of cancer beside H&E Stained biopsy report,. once IHC has given report of biopsy , majority time we have to believe its finding of it and start treatment as per its report. if its lymphoma then treatment is chemotherapy followed by radiotherapy to local site, if its sarcoma treatment is chemo , if it turns plasmacytoma then radiotherapy after skeletal survey of whole body to rule out possibility of multiple myeloma.