HI I was on Effexor xr for about 12 years and they worked so well for until the day came when I found they where no longer working for me even on the highest dose so after my doctor tried me on other anti depression tablets he has told me to settle on pristiq but after being on them for nearly 4 months I feel they are doing nothing for me , my depression was and is getting worse so I told the doctor and he gave me a letter for a physicolist but that is not helping with my every day living , I have the I cant be bothered attidute, cant get out of bed, and a whole lot more and i am at the point I don't know what I am going to do next