Hi, I have PVC s and PAC s for about three years now. Structurally normal heart and no other health problems. Holter EKG a year ago recorded a little over 3.000 PVC s and about 500 PAC s. I m taking sotalol (2X40 mg) for about a year. At first it worked great, but the last couple of months PVC s are back. Sometimes they go away for a couple of weeks and then they return really strong. The thing that worries me is that i used to have them mostly when resting or before bed and now I have them most of the time during any kind of physical activity - is there a reason to be concerned about this? And what do you think about sotalol as therapy for pvc s? Thanks a lot.