Hello! Thanks for being with us. Oxyelite is a herbal cum chemical weight loss supplement that is used as a natural fat burner to help users lose weight. While the drug can have a significant effect on a person s weight loss abilities, it can also lead to uncomfortable side effects like menstrual irregularities,heart problems and excessive sweating and more. There is no documented evidence or study regarding the drug interaction between coumadin and and oxyelite. As coumarin is very essential for you than oxyelite and coumadin has very narrow therapeutic range it is better to avoid taking oxyelite. You can use other form of therapy for weight reduction with doctor s consultation. Hope you have satisfied with the answer. For more queries you can write to us. Wish you good health.