i have only one symptom that mystifies A DOZEN doctors for years who are puzzled--I'm a 65 year old athlete who has found the fountain of youth in every aspect and have incredible good health,vegetarian diet and daily exercise program ..No drinking smoking or alcohol---Just strong coffee every morning....All blood lab tests perfect including cortisol.I am on testosterone shots by doctor for 5 years. I BOUNCE AROUND LIKE A TEENAGER----- PROBLEM : ALL MY SKELETAL MUSCLES,TENDONS AND LIGAMENTS , for the last 7 years , ARE ALL LOCKED UP,STIFF AND SEVERE ACHE, WITH THE ONES CLOSEST TO MY MID SECTION BEING THE WORST AND SAID LOCK-UP DECREASING IN MUSCLES THE FURTHER FROM THE MID-SECTION.. I don't take any meds except bromocryptine for a pituitary tumor...My legs are weaker than a childs..All leg hair is gone. NO DIAGNOSIS EXCEPT MINE THAT BEING "LEAKY GUT SYNDROME"...