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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Can Macrophage Activation Syndrome Be Treated And Managed?

hi my 2 year old daughter was diagnosed with macrophage activation syndrome last year after she had her MMR + Chicken pox shot. She was treated for the MAS and has been on steroids and cyclosporine for last 6 months. One of the MAS symptoms was red rash all over her body and fever. That all cleared away with the meds but it is now coming back since reducing her steroids to bare minimum. It comes and goes throughout the day. When we give her a bath it goes away as if it were regulated by heat. Stress and agitation and tiredness seems to bring the rash out. A part from being told it is an immune deficiency (my daughter was born 3 months premature) the docs don t seem to have a better diagnosis. Any ideas? tx
Tue, 27 Jun 2017
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Pediatrician,  's  Response
Coagulation profile is often abnormal in MAS which may lead to easy bruising, rash, mucosal bleeding etc.
During follow-up visits your doctor will do required blood investigations to make sure all parameters are within acceptable range.
As long as coagulation profile and platelets are within normal range, rash alone is not a significant clinical problem in MAS.
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How Can Macrophage Activation Syndrome Be Treated And Managed?

Coagulation profile is often abnormal in MAS which may lead to easy bruising, rash, mucosal bleeding etc. During follow-up visits your doctor will do required blood investigations to make sure all parameters are within acceptable range. As long as coagulation profile and platelets are within normal range, rash alone is not a significant clinical problem in MAS.