Hi,
Cannabis is used for recreational and medical purposes. It can be taken orally or
smoking or through nasal route. Inhalation of the
tetrahydrocannabinol has rapid action between 3 to 10 minutes. By oral route, it may take upto two hours for
metabolism and absorption. Bioavailability is more in oral route compared to inhalational route.
Tetrahydrocannabinol is distributed mostly in plasma about 90 percent and rest in red blood cells. It gets deposited in fat tissue. In oral route, the maximum active compounds deposit in brain and muscles than the blood. Later the plasma concentration increased by fat redistribution.
In occasional users, half life is about less than one and quarter days. But it is more for about 27 days in chronic users. About sixty five percent of the drug get excreted via feces, twenty percent via urine after metabolized by
liver into water soluble metabolites. Complete excretion may take about seven to ten days in occasional users. But more in chronic users.
Take care. Hope I have answered your question. Let me know if I can assist you further.
Regards,
Dr. Pradeepraj, General & Family Physician