Hi, Individual variation exists for the response to be observed, but in general, it can be effective within six months. Metformin is ideal when insulin resistance is observed and this helps to get spontaneous ovulation. Once regular ovulation is established, monitoring and conception is possible. To this end, it is possible when the contraceptive pills are withdrawn since they are meant to regularize the cycles and simultaneously inhibit ovulation. Please maintain a healthy weight, regular exercise and a healthy diet. Hope this helps.