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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How To Control Cholesterol Levels?

I had a TIA two years back now I am Ok taking BP and aspirin and cholesterol reducing tablets regularly but when I stop taking cholesterol reducing tablets my cholesterol level goes high so I have to take it regularly but this causes my SGPT to be increased and I stop taking it but when I stop taking atorvastatin tablets my cholesterol level again goes High so is there any solution that My cholesterol level and my SGPT be in limited range or there any other medicine that I can take regularly to reduce my cholesterol level without increasing my SGPT. Plz suggest me thanking you
Wed, 2 Nov 2016
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Cardiologist 's  Response
I would suggest talking to your doctor about this question. Some people are sensitive to the liver-irritating effects of the entire statin drug class (SGPT is one of the "liver enzymes" that we follow to make sure the liver is not being irritated or inflamed). Atorvastatin is a cholesterol-lower and stroke-preventing medication in the statin drug class. Its chemical structure is a bit different from other statins, so it is possible that your liver might be irritated by Atorvastatin but not by another statin with a slightly different chemical structure, such as Pravastatin or Rosuvastatin. Also, sometimes the vitamin supplement Coenzyme Q-10 can help to prevent some side effects of the statin drugs, so this is something you should ask your doctor about, as well. Furthermore, if the Atorvastatin is stopped but the SGPT remains elevated, a Hepatitis Viral panel should be checked to see if the liver is being irritated from a virus, rather than a drug. If hepatitis and other viruses are ruled out, a liver sonogram might be indicated to check the health of the liver. Statins are the only class of cholesterol-lowering medications that have been proven to reduce the risk of strokes in people who have had TIA's, so hopefully these above suggestions might make it possible for you to remain on treatment with a statin. There are a small percentage of people, however, whose bodies just are not able to tolerate any drug in the class. Good luck.
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How To Control Cholesterol Levels?

I would suggest talking to your doctor about this question. Some people are sensitive to the liver-irritating effects of the entire statin drug class (SGPT is one of the liver enzymes that we follow to make sure the liver is not being irritated or inflamed). Atorvastatin is a cholesterol-lower and stroke-preventing medication in the statin drug class. Its chemical structure is a bit different from other statins, so it is possible that your liver might be irritated by Atorvastatin but not by another statin with a slightly different chemical structure, such as Pravastatin or Rosuvastatin. Also, sometimes the vitamin supplement Coenzyme Q-10 can help to prevent some side effects of the statin drugs, so this is something you should ask your doctor about, as well. Furthermore, if the Atorvastatin is stopped but the SGPT remains elevated, a Hepatitis Viral panel should be checked to see if the liver is being irritated from a virus, rather than a drug. If hepatitis and other viruses are ruled out, a liver sonogram might be indicated to check the health of the liver. Statins are the only class of cholesterol-lowering medications that have been proven to reduce the risk of strokes in people who have had TIA s, so hopefully these above suggestions might make it possible for you to remain on treatment with a statin. There are a small percentage of people, however, whose bodies just are not able to tolerate any drug in the class. Good luck.