Hello Thank You for contacting HCM. I read your query carefully. No ,its not possible to stop If you abruptly stop taking prednisone or taper off too quickly, you might experience prednisone withdrawal symptoms: Severe fatigue Weakness Body aches Joint pain Prednisone is similar to cortisol, a hormone naturally made by your adrenal glands. A gradual reduction in prednisone dosage gives your adrenal glands time to resume their normal function. I would like to advise you visit your doctor and ask him to reduce your dose. Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. Wishing you good health.