I have a prescription for 1 mg. of Alprazolam at bedtime daily. I can't go to sleep without it. I will be attending a bachelorette party this weekend, and will be drinking...possibly heavy. My drink of choice is vodka, if that makes a difference. I only drink a couple times a year, so I have no idea if it is safe for me to take my medicine before I go to bed. I would probably be going to bed about an hour after leaving the party.