I have taken Arthrotec for 30 years and it has not bothered me. Recently in Canada my twice daily dose of 75 mg. was ordered reduced to twice daily 50 mg. not quite as effective but still good. Now I am cold that it is bothering my Kidney's my Creatinine level is 125 what ever that means...I don't know if it is dangerously high or a bit high. They advised I STOP taking Arthrotec ... I am using Tylenol Arthritis but it also has scary side effects...without it my mobility is bad and the pain is great I don't want to develop Kidney disease but I need something.