I went to my dr for new birth control because I was told it could help with my depression. Lately I've been having some sadness and I thought my horomones may be off. I was told no for the pill bc I have migraines, so I researched that estrogen alone could help depression. Since I'm not sexually active, what do you think about trying an estrogen supplement over the counter? I'm 30. I was on the depo for 7 years, but stopped taking it in may of this year. Even though I get pms, I have no gotten my period back and they say you never know when it will come back. It stopped about a year after I started taking it.