I'm looking for a safe anti-depressant as recommended by my doctor. I have extreme anxiety and I am presently taking Lorazepam but my doctor wants me to get off the LOrazepam and take an anti-depressant. Zoloft or Flexipro are recommended. I have taken Zoloft succesfully about 10 years ago, but I was not taking Lorazepam at that time. I am taking Lorazepam now, so I need a safe anti-depressant that I can use with Lorazepam until I can slowly discontinue the Lorazepam. Any suggestions? I am ready to use Flexipro now starting at a low dose of 2.5mg but I'm thinking I should go back to Zoloft since I was successful with it years ago, but I am also taking Lorazepam. Can i safely mix Lorazepam and Zoloft ?