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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Cymbalta Advisable Over Zoloft?

I am currently taking Zoloft but am experiencing severe depressive episodes which last up to three days at least every other month. I know that Zoloft affects serotonin and I am wondering if either Cymbalta, which affects serotonin & norephinephrine or Wellbutrin, which affects norephinephrine & dopamine, would be a better option.
Tue, 12 Jun 2018
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Addiction Medicine Specialist 's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

Cymbalta has never been superior to Zoloft on treating depression. It has more side effects and a lower safety margin. But, it has effects on pain that Zoloft does not.
Also, individuals vary on responses to medications. Some people prefer one some prefer another.

Hope I have answered your query. Let me know if I can assist you further.
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Is Cymbalta Advisable Over Zoloft?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Cymbalta has never been superior to Zoloft on treating depression. It has more side effects and a lower safety margin. But, it has effects on pain that Zoloft does not. Also, individuals vary on responses to medications. Some people prefer one some prefer another. Hope I have answered your query. Let me know if I can assist you further.